| In 1982 antineutrophil antibodies have been first
reported in a few patients suffering from necrotising
glomerulonephritis. This lead to the discovery of
immunodiagnostic extremely important autoantibodies,
that are detected in systemic vasculitic disorders.
Proteinase 3 is the classical autoantigen in Wegener's
granulomatosis. About 2/3 of patients in the initial
phase of the disease course exhibit Anti-PR3. During
active phases Anti-PR3 can be detected in more than
95% of all patients. Anti-PR3 antibodies are directed
against the lysosomal enzyme Proteinase 3 located in
neutrophil granulocytes and monocytes.
The anti-PR3 test is also available as high sensitive version (ORG 618). |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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| Range |
0 – 100 U/ml |
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| Cut-off |
5 U/ml |
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| Sensitivity |
0.5 U/ml |
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| Calibration |
arbitrary |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 518-0508-01-gb.pdf
Material-Safety-Datasheet: ORG 518.pdf