| Primarily, Goodpasture syndrome is an autoimmune
disorder of the kidneys. Ernest Goodpasture, an
American pathologist was the first in 1919 who
described the coexistence of a fatal lung hemorrhage
coming along with proliferative glomerulonephritis in
a young man. The syndrome is now considered as an
autoimmune disorder consisting of the triad of
glomerulonephritis, lung hemorrhage and antiglomerular
basement antibodies formation. The reactivity of
Goodpasture specific Anti-GBM autoantibodies is
directed against the 29 kDa NC1 domain of the
a-3-chain of type IV collagen of GBM. After the target
antigen has been entirely characterized nowadays the
triad of glomerulonephritis, lung hemorrhage and the
antibodies against the a-3-chain of type IV collagen of
GBM are the essential elements of diagnosis of
Goodpasture syndrome. ELISA test systems provided
with the corresponding pure antigen exhibit sensitivities
and specificities of about 98 to 99%. |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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| Range |
0 – 200 U/ml |
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| Cut-off |
20 U/ml |
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| Sensitivity |
1 U/ml |
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| Calibration |
arbitrary |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 550-0508-01-gb.pdf
Material-Safety-Datasheet: ORG 550.pdf