| Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies against native double stranded DNA (dsDNA). Additionally, these patients also exhibit autoantibodies against the single stranded
form of DNA. Together with the determination of
antinuclear antibodies (ANA) the determination of
dsDNA antibodies is the most important serological
criteria for diagnosing SLE. Autoantibodies against
dsDNA have a diagnostic specificity of about 96% and a sensitivity of about 91% for diagnosing SLE. Anti‑dsDNA antibodies are useful to monitor therapy and to predict disease progression.
In the Anti-dsDNA as well in the Anti‑ssDNA kit human recombinant DNA is used as antigen. Thus the Anti‑dsDNA kit permits the detection of the lupus-specific
autoantibodies with excellent sensitivity and specificity. |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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| Range |
0 – 200 IU/ml and U/ml, resp. |
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| Cut-off |
20 IU/ml (and U/ml, resp.)
Screen: 25 U/ml |
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| Sensitivity |
1 IU/ml and 1 U/ml, resp. |
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| Calibration |
WHO Wo/80 (IgG dsDNA) |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 604-0508-01-gb.pdf
Material-Safety-Datasheet: ORG 604.pdf