| Anti-Nucleosome antibodies are recognised to be
especially prevalent in systemic lupus erythemashy;tosus and drug-induced lupus.
Nucleosomes mainly consist of an octamere of histones around which DNA winds. The nucleosome structure is important in the compaction of DNA in the nucleus. It could be demonstrated, that anti-Nucleosome antibodies are detected in 84 ‑ 88 % of patients with SLE.
It has been reported that anti‑Nucleosome immunglobulin G antibodies like anti‑dsDNA antibodies are a
sensitive marker of SLE, and are almost exclusively
found in lupus, scleroderma and mixed connective tissue diseases. Anti‑Nucleosome antibodies are detected at an earlier
stage than anti‑dsDNA antibodies. |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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| Range |
0 – 200 U/mL |
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| Cut-off |
20 U/mL |
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| Sensitivity |
0.5 U/mL |
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| Calibration |
Arbitrary |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 528-0508-01-gb.pdf
Material-Safety-Datasheet: ORG 528.pdf