| The term inflammatory rheumatic diseases refers to
diseases of unknown origin with humoral and cellular disturbances, systemic organ failure and chronic disease. Additionally mixed connective tissue diseases are characterized by overlapping symptoms, thus making them difficult to diagnose.
When a systemic autoimmune disease is suspected a common practice is the performance of a general
screening test for antinuclear antibodies. The wells of the ANAscreen test are coated with a mixture of
8 different antigens: RNP‑70 (70 kDa protein of the U1‑snRNP-complex), RNP/Sm, Sm, SS‑A (52 and 60 kDa), SS‑B, Scl‑70, Centromere B und Jo‑1. This
assay permits a sensitive screening for the corresponding antinuclear antibodies in a patient serum. An ANAscreen positive serum should be further tested in the ANAcombi (ORG 539) test. |
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| Tests |
12 x 8 Tests |
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| Calculation |
qualitative |
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| Range |
Index-Value |
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| Cut-off |
CDC |
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| Sensitivity |
TMB / 450 nm |
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| Calibration |
RNP-70, RNP/Sm, Sm, SS-A, SS-B,
Scl-70, Centromere B, Jo-1 |
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Instruction for Use: ORG 538-0509-01-gb.pdf
Material-Safety-Datasheet: ORG 538.pdf