| Up to 80% of all patients suffering from systemic
lupus erythematosus manifest autoantibodies against
the histone proteins H1, H2A, H2B, H3 and H4. Usually
these patients also exhibit anti-dsDNA antibodies.
More frequently histone antibodies are detected in
patients with drug induced lupus syndromes, e g. after
taking drugs such as hydralazine und procainamide.
The number of positive findings in these patients can
rise to 95%, dependent on the drug. However, antidsDNA
antibodies are absent. Additionally, anti-histone
antibodies can occur in patients suffering from
primary biliary cirrhosis, rheumatoid arthritis and
scleroderma. |
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 |
 |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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|
|
| Range |
0 – 200 U/ml |
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| Cut-off |
40 U/ml |
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|
| Sensitivity |
1 U/ml |
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|
|
| Calibration |
MRC 66/233 |
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|
| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 507-0508-01-gb.pdf
Material-Safety-Datasheet: ORG 507.pdf