| Hashimoto's thyroiditis, primary myxedema and
Grave's disease (along with ophtalmopathia) are
important autoimmune disorders of the thyroid.
Autoantibodies against thyroglobulin and thyroid
peroxidase are characteristic serological features of
these diseases.
Thyroglobulin (hTg), a water soluble glycoprotein
with a molecular weight of approx. 660.000 Dalton,
is the principal constituent of the thyroidal colloid
sharing about 75 % of it's mass. Synthesis of the thyroid
hormones T3 and T4 is based on the oxidative
iodination of tyrosine residues of the thyroglobulin
molecule. Within the cell thyroglobulin is transported
by the microsomes. Together with the secretion of
T3 and T4 also small amounts of hTg are liberated into
circulation.
This assay is also available in pinplate format. |
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| Tests |
ORG 502: 12 x 8 Tests
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| Calculation |
quantitative |
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| Range |
0 – 9000 IU/ml |
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| Cut-off |
ORG 502: 150 IU/ml
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| Sensitivity |
10 IU/ml |
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| Calibration |
WHO 65/93 |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 502-0604-02-gb.pdf
Material-Safety-Datasheet: ORG 502.pdf