| The serum protein β2-Glycoprotein I (β2-GPI, Apolipoprotein
H) not only is an important cofactor for the
detection of anti-phospholipid antibodies (e.g. Anti-Cardiolipin). It also plays a crucial role as independent
autoantigenic target. The detection of anti-β2-Glycoprotein I anti-
bodies in the sera of patients suffering
from anti-phospholipid syndrome along with clinical
manifestations of thrombosis, thrombocytopenia and
recurrent fetal loss has been repeatedly described.
β2-GPI is a 50 kDa globulin occurring in plasma at a
level of 200 µg/ml. β2-GPI is associated in vivo with
negatively-charged substances, e.g. anionic phospholipids,
heparin and lipoproteins. The phospholipid
binding region is located on its fifth domain. |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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| Range |
0 – 100 U/ml |
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| Cut-off |
8 U/ml |
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| Sensitivity |
0.5 U/ml |
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| Calibration |
Harris, IRP 97/656 (IgG) |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 521-0509-01-gb.pdf
Material-Safety-Datasheet: ORG 521.pdf