| The family of aPL antibodies has recently expanded to
include a heterogeneous group of antibodies whose
specificity is directed against phospholipid binding
proteins or their complex with phospholipids.
Prothrombin (factor II of the blood coagulation) is a
phospholipid binding protein, that exerts a procoagulant
activity via a prothrombinase complex, triggering
fibrinogen conversion to fibrin. The presence of antibodies
to prothrombin is associated with thrombosis
in patients with SLE and APS. And it was found that
high autoantibody levels against prothrombin are
associated with deep venous thrombosis, pulmonary
embolism and myocardial infarction. |
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|
 |
 |
|
| Tests |
12 x 8 Tests |
|
|
|
|
| Calculation |
quantitative |
|
|
|
|
| Range |
0 – 100 U/ml |
|
|
|
|
| Cut-off |
10 U/ml
Screen: 20 U/ml |
|
|
|
|
| Sensitivity |
1 U/ml |
|
|
|
|
| Calibration |
arbitrary |
|
|
|
|
| Substrate |
TMB / 450 nm |
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|
Instruction for Use: ORG 541-0508-01-gb.pdf
Material-Safety-Datasheet: ORG 541.pdf